{ "summary": { "updated_at": "2026-08-08", "supported_proteins": 581, "not_supported_by_ML": 12, "no_model_only": 12, "capacity_tiers": { "medium_3_5": 55, "high_6_9": 19, "low_1_2": 12, "none": 3 } }, "strain_capacity": [ { "strain": "07C", "ML_verified_modules": 3, "modules_with_strong_clinker": 0, "capacity_tier": "medium_3_5" }, { "strain": "14696", "ML_verified_modules": 4, "modules_with_strong_clinker": 1, "capacity_tier": "medium_3_5" }, { "strain": "15dZY3bin51", "ML_verified_modules": 3, "modules_with_strong_clinker": 1, "capacity_tier": "medium_3_5" }, { "strain": "17bor14", "ML_verified_modules": 5, "modules_with_strong_clinker": 4, "capacity_tier": "medium_3_5" }, { "strain": "2CP1", "ML_verified_modules": 4, "modules_with_strong_clinker": 1, "capacity_tier": "medium_3_5" }, { "strain": "341R", "ML_verified_modules": 3, "modules_with_strong_clinker": 1, "capacity_tier": "medium_3_5" }, { "strain": "3LFB2", "ML_verified_modules": 5, "modules_with_strong_clinker": 3, 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"modules_with_strong_clinker": 1, "capacity_tier": "medium_3_5" }, { "strain": "DSM436", "ML_verified_modules": 3, "modules_with_strong_clinker": 1, "capacity_tier": "medium_3_5" }, { "strain": "DSM52655", "ML_verified_modules": 9, "modules_with_strong_clinker": 9, "capacity_tier": "high_6_9" }, { "strain": "DSM53668", "ML_verified_modules": 3, "modules_with_strong_clinker": 0, "capacity_tier": "medium_3_5" }, { "strain": "DSM71", "ML_verified_modules": 4, "modules_with_strong_clinker": 0, "capacity_tier": "medium_3_5" }, { "strain": "DW43-1", "ML_verified_modules": 7, "modules_with_strong_clinker": 7, "capacity_tier": "high_6_9" }, { "strain": "DZF1", "ML_verified_modules": 5, "modules_with_strong_clinker": 3, "capacity_tier": "medium_3_5" }, { "strain": "EGB", "ML_verified_modules": 5, "modules_with_strong_clinker": 3, "capacity_tier": "medium_3_5" }, { "strain": "GCF_015354265.1_ASM1535426v1_genomic", "ML_verified_modules": 5, "modules_with_strong_clinker": 4, "capacity_tier": 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"共线性支持至少一个Step3功能，但存在多功能、部分簇或底物特异性歧义。", "synteny_evidence": "A_GlcNag_fusion:PTS_EI:partial_context;A_GlcNag_fusion:PTS_HPR:partial_context;C_FruTag_fusion:PTS_EI:partial_context;C_FruTag_fusion:PTS_EIIA_FRU:partial_context;C_FruTag_fusion:PTS_HPR:partial_context", "strong_supported_roles": "none", "partial_supported_roles": "PTS_EI;PTS_EIIA_FRU;PTS_HPR", "substrate_ambiguous_roles": "none", "grade_rank": 2, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "15dZY3bin51", "protein_id": "BNBBMMJG_01628", "step3_roles_all": "PTS_EIIA_FRU", "cluster_applicable_roles": "PTS_EIIA_FRU", "synteny_supported_roles": "PTS_EIIA_FRU", "unsupported_applicable_roles": "none", "grade": "B", "grade_subtype": "B_context_supported_but_ambiguous", "require_3Di": true, "reason_zh": "共线性支持至少一个Step3功能，但存在多功能、部分簇或底物特异性歧义。", "synteny_evidence": "C_FruTag_fusion:PTS_EIIA_FRU:partial_context", "strong_supported_roles": "none", "partial_supported_roles": "PTS_EIIA_FRU", "substrate_ambiguous_roles": "none", "grade_rank": 2, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "2CP1", "protein_id": "EGJCCMIL_04340", "step3_roles_all": "MAL_T", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", "grade": "B", "grade_subtype": "B_context_supported_but_ambiguous", "require_3Di": true, "reason_zh": "共线性支持至少一个Step3功能，但存在多功能、部分簇或底物特异性歧义。", "synteny_evidence": "G_TreMal_ABC:SugB:partial_context", "strong_supported_roles": "none", "partial_supported_roles": "MAL_T", "substrate_ambiguous_roles": "none", "grade_rank": 2, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "341R", "protein_id": "DDHPOEJE_00303", "step3_roles_all": "PTS_EIIA_FRU", "cluster_applicable_roles": "PTS_EIIA_FRU", "synteny_supported_roles": "PTS_EIIA_FRU", "unsupported_applicable_roles": "none", "grade": "B", "grade_subtype": "B_context_supported_but_ambiguous", "require_3Di": true, "reason_zh": "共线性支持至少一个Step3功能，但存在多功能、部分簇或底物特异性歧义。", "synteny_evidence": "C_FruTag_fusion:PTS_EIIA_FRU:partial_context", "strong_supported_roles": "none", "partial_supported_roles": "PTS_EIIA_FRU", "substrate_ambiguous_roles": "none", "grade_rank": 2, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "341R", "protein_id": "DDHPOEJE_00306", "step3_roles_all": "PTS_HPR", "cluster_applicable_roles": "PTS_HPR", "synteny_supported_roles": "PTS_HPR", "unsupported_applicable_roles": "none", "grade": "B", "grade_subtype": "B_context_supported_but_ambiguous", "require_3Di": true, "reason_zh": "共线性支持至少一个Step3功能，但存在多功能、部分簇或底物特异性歧义。", "synteny_evidence": "A_GlcNag_fusion:PTS_HPR:partial_context;C_FruTag_fusion:PTS_HPR:partial_context", "strong_supported_roles": "none", "partial_supported_roles": "PTS_HPR", "substrate_ambiguous_roles": "none", "grade_rank": 2, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "341R", "protein_id": "DDHPOEJE_00307", "step3_roles_all": "PTS_EI", "cluster_applicable_roles": "PTS_EI", "synteny_supported_roles": "PTS_EI", "unsupported_applicable_roles": "none", "grade": "B", "grade_subtype": "B_context_supported_but_ambiguous", "require_3Di": true, "reason_zh": "共线性支持至少一个Step3功能，但存在多功能、部分簇或底物特异性歧义。", "synteny_evidence": "A_GlcNag_fusion:PTS_EI:partial_context;C_FruTag_fusion:PTS_EI:partial_context", "strong_supported_roles": "none", "partial_supported_roles": "PTS_EI", "substrate_ambiguous_roles": "none", "grade_rank": 2, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "3LFB2", "protein_id": "PONAEGIB_07496", "step3_roles_all": "PTS_EI", "cluster_applicable_roles": "PTS_EI", "synteny_supported_roles": "PTS_EI", "unsupported_applicable_roles": "none", "grade": "B", "grade_subtype": "B_context_supported_but_ambiguous", "require_3Di": true, "reason_zh": "共线性支持至少一个Step3功能，但存在多功能、部分簇或底物特异性歧义。", "synteny_evidence": "C_FruTag_fusion:PTS_EI:partial_context", "strong_supported_roles": "none", "partial_supported_roles": "PTS_EI", "substrate_ambiguous_roles": "none", "grade_rank": 2, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "3LFB2", "protein_id": "PONAEGIB_07498", "step3_roles_all": "PTS_EIIA_MAN;PTS_EIIC_MFS", "cluster_applicable_roles": "PTS_EIIA_MAN;PTS_EIIC_MFS", "synteny_supported_roles": "PTS_EIIA_MAN;PTS_EIIC_MFS", 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"HIFBOLJK_12256", "step3_roles_all": "PTS_HPR", "cluster_applicable_roles": "PTS_HPR", "synteny_supported_roles": "PTS_HPR", "unsupported_applicable_roles": "none", "grade": "B", "grade_subtype": "B_context_supported_but_ambiguous", "require_3Di": true, "reason_zh": "共线性支持至少一个Step3功能，但存在多功能、部分簇或底物特异性歧义。", "synteny_evidence": "A_GlcNag_fusion:PTS_HPR:partial_context;C_FruTag_fusion:PTS_HPR:partial_context", "strong_supported_roles": "none", "partial_supported_roles": "PTS_HPR", "substrate_ambiguous_roles": "none", "grade_rank": 2, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "5N486", "protein_id": "HIFBOLJK_12257", "step3_roles_all": "PTS_EI", "cluster_applicable_roles": "PTS_EI", "synteny_supported_roles": "PTS_EI", "unsupported_applicable_roles": "none", "grade": "B", "grade_subtype": "B_context_supported_but_ambiguous", "require_3Di": true, "reason_zh": 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"reason_zh": "蛋白处于强保守簇核心位置，但Step3功能与该位置预期功能直接冲突。", "synteny_evidence": "F_Arabinose_ABC:AraB:strong_conflict", "strong_supported_roles": "none", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 3, "final_protein_status": "not_supported_by_ML", "final_support_source": "BCD_ML_negative_or_missing", "ml_protein_level_status": "only_negative" }, { "strain": "Soce10", "protein_id": "OEIAKBBC_04381", "step3_roles_all": "GLPK;XYL_B", "cluster_applicable_roles": "XYL_B", "synteny_supported_roles": "none", "unsupported_applicable_roles": "XYL_B", "grade": "C", "grade_subtype": "C_direct_function_conflict_at_conserved_position", "require_3Di": true, "reason_zh": "蛋白处于强保守簇核心位置，但Step3功能与该位置预期功能直接冲突。", "synteny_evidence": "F_Arabinose_ABC:AraB:strong_conflict", "strong_supported_roles": "none", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 3, "final_protein_status": "not_supported_by_ML", "final_support_source": 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"final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "AC19", "protein_id": "DLFDNEPA_05138", "step3_roles_all": "none", "cluster_applicable_roles": "XYL_B", "synteny_supported_roles": "XYL_B", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "H_Xylulose_Polyol_ABC:XylB:strong", "strong_supported_roles": "XYL_B", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "ATCC29037", "protein_id": "DEBHHDAO_05664", "step3_roles_all": "none", "cluster_applicable_roles": "XYL_B", "synteny_supported_roles": "XYL_B", "unsupported_applicable_roles": "none", "grade": 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"final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "Ag2", "protein_id": "MCODGPEK_07621", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "G_TreMal_ABC:SugB:strong", "strong_supported_roles": "MAL_T", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "BDFP2", "protein_id": "MIMNIOPI_02360", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", 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"蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "G_TreMal_ABC:SugB:strong", "strong_supported_roles": "MAL_T", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "KYC3313", "protein_id": "NMDAKICD_04621", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "G_TreMal_ABC:SugB:strong", "strong_supported_roles": "MAL_T", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "NCWAL01", "protein_id": "GKLHGIJB_06466", "step3_roles_all": "none", "cluster_applicable_roles": "XYL_B", "synteny_supported_roles": "XYL_B", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "H_Xylulose_Polyol_ABC:XylB:strong", "strong_supported_roles": "XYL_B", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "Pendulispora_albinea", "protein_id": "POLBKJFM_01545", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "G_TreMal_ABC:SugB:strong", "strong_supported_roles": "MAL_T", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "Pendulispora_brunnea", "protein_id": "CIEBNLDA_02374", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "G_TreMal_ABC:SugB:strong", "strong_supported_roles": "MAL_T", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "Pendulispora_rubella", "protein_id": "AGCBJLIN_02414", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "G_TreMal_ABC:SugB:strong", "strong_supported_roles": "MAL_T", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "S1.all", "protein_id": "CCLGAHEJ_06988", "step3_roles_all": "none", "cluster_applicable_roles": "XYL_B", "synteny_supported_roles": "XYL_B", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "H_Xylulose_Polyol_ABC:XylB:strong", "strong_supported_roles": "XYL_B", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "SDU13", "protein_id": "IENIBONI_09065", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "G_TreMal_ABC:SugB:strong", "strong_supported_roles": "MAL_T", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "SMAGU13373", "protein_id": "LIIAAFLO_02258", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "G_TreMal_ABC:SugB:strong", "strong_supported_roles": "MAL_T", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "SMAGU13669", "protein_id": "FIJOFCLH_00507", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "G_TreMal_ABC:SugB:strong", "strong_supported_roles": "MAL_T", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "SZUA566", "protein_id": "GIJMIOEG_02809", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "G_TreMal_ABC:SugB:strong", "strong_supported_roles": "MAL_T", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "So0003192", "protein_id": "EBGKBIFC_08267", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", "unsupported_applicable_roles": "none", "grade": "D", "grade_subtype": "D_strong_core_position_but_Step3_missed", "require_3Di": true, "reason_zh": "蛋白位于强保守簇的对应核心位置，但Step3未识别预期功能，属于潜在漏检。", "synteny_evidence": "G_TreMal_ABC:SugB:strong", "strong_supported_roles": "MAL_T", "partial_supported_roles": "none", "substrate_ambiguous_roles": "none", "grade_rank": 4, "final_protein_status": "final_supported", "final_support_source": "BCD_ML_positive_or_borderline", "ml_protein_level_status": "has_ML_positive" }, { "strain": "Soce10", "protein_id": "OEIAKBBC_05500", "step3_roles_all": "none", "cluster_applicable_roles": "MAL_T", "synteny_supported_roles": "MAL_T", 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